发表论文

代表性论文

1.Yang S, Tong Y, Chen L, Yu W. Human Identical Sequences, hyaluronan, and hymecromone ─ the new mechanism and management of COVID-19. Mol Biomed. 2022 May 20;3(1):15. doi: 10.1186/s43556-022-00077-0. PMID: 35593963.

2. Shuai Yang#, Yun Ling#, Fang Zhao#, Wei Li, Zhigang Song, Lu Wang, Qiuting Li, Mengxing Liu, Ying Tong, Lu Chen, Daoping Ru, Tongsheng Zhang, Kaicheng Zhou, Baolong Zhang, Peng Xu, Zhicong Yang, Wenxuan Li, Yuanlin Song, Jianqing Xu, Tongyu Zhu, Fei Shan*, Wenqiang Yu* & Hongzhou Lu*. Hymecromone: a clinical prescription hyaluronan inhibitor for efficiently blocking COVID-19 progression. Sig Transduct Target Ther 7, 91 (2022). https://doi.org/10.1038/s41392-022-00952-w

3. Wei Li#, Shuai Yang#, Peng Xu#, Dapeng Zhang#, Ying Tong#, Lu Chen#, Ben Jia, Ang Li, Cheng Lian, Daoping Ru, Baolong Zhang, Mengxing Liu, Cancan Chen, Weihui Fu, Songhua Yuan, Chenjian Gu, Lu Wang, Wenxuan Li, Ying Liang, Zhicong Yang, Xiaoguang Ren, Shaoxuan Wang, Xiaoyan Zhang, Yuanlin Song, Youhua Xie, Hongzhou Lu, Jianqing Xu*, Hailin Wang*, Wenqiang Yu*. SARS-CoV-2 RNA elements share human sequence identity and upregulate hyaluronan via NamiRNA-enhancer network. EBioMedicine. 2022 Feb 3;76:103861. doi: 10.1016/j.ebiom.2022.103861.

4. Ying Liang#, Qi Lu#, Wei Li#, Dapeng Zhang#, Fanglin Zhang#, Qingping Zou, Lu Chen, Ying Tong, Mengxing Liu, Shaoxuan Wang, Wenxuan Li, Xiaoguang Ren, Peng Xu, Zhicong Yang, Shihua Dong, Baolong Zhang, Yanni Huang, Daqiang Li*, Hailin Wang*, Wenqiang Yu*. Reactivation of tumour suppressor in breast cancer by enhancer switching through NamiRNA network. Nucleic Acids Res. 2021 Sep 7;49(15):8556-8572. doi: 10.1093/nar/gkab626.

5. Shihua Dong#, Qi Lu#, Peng Xu#, Limei Chen#, Xiaoling Duan, Zhanrui Mao, Baolong Zhang, Long Sui*, Yudong Wang*, Wenqiang Yu*. (2021) Hypermethylated PCDHGB7 as a universal cancer only marker and its application in early cervical cancer screening. Clin Transl Med. 2021 Jun;11(6):e457. doi: 10.1002/ctm2.457.

6. Peng Xu#, Lan Zhang#, Yao Xiao#, Wei Li#, Zhiqiang Hu#, Rukui Zhang, Jin Li, Feizhen Wu, Yanping Xi, Qingping Zou, Zhentian Wang, Rui Guo, Honghui Ma, Shihua Dong, Min Xiao, Zhicong Yang, Xiaoguang Ren, Chaochun Wei*, Wenqiang Yu*. (2021) UHRF1 regulates alternative splicing by binding to splicing factors and U snRNAs. Hum Mol Genet. 2021 Nov 1;30(22):2110-2122. doi: 10.1093/hmg/ddab178.

7. Shihua Dong#, Wei Li#, Lin Wang#, Jie Hu#, Yuanlin Song#, Baolong Zhang, Xiaoguang Ren, Shimeng Ji, Jin Li, Peng Xu , Ying Liang, Gang Chen, Jia-Tao Lou*, Wenqiang Yu*. (2019) Histone-Related Genes Are Hypermethylated in Lung Cancer and Hypermethylated HIST1H4F Could Serve as a Pan-Cancer Biomarker. Cancer Res. Dec 15;79(24):6101-6112. doi: 10.1158/0008-5472.

8. Li J#, Li Y#, Li W#, Luo H#, Xi Y#, Dong S#, Gao M#, Xu P, Zhang B, Liang Y, Zou Q, Hu X, Peng L, Zou D, Wang T, Yang H, Jiang C, Peng S*, Wu F*, Yu W*.  (2019) Guide Positioning Sequencing identifies aberrant DNA methylation patterns that alter cell identity and tumor-immune surveillance networks. Genome Res. 2019 Feb;29(2):270-280. doi: 10.1101/gr.240606.118. Epub 2019 Jan 22.

9. Liang Y#, Xu P#, Zou Q#, Luo H, Yu W*. (2019) An epigenetic perspective on tumorigenesis: Loss of cell identity, enhancer switching, and NamiRNA network. Semin Cancer Biol. 2019 Aug;57:1-9. doi: 10.1016/j.semcancer.2018.09.001.

10. Zou Q, Xiao X, Liang Y, Peng L, Guo Z, Li W, Yu W*. (2018) miR-19a-mediated downregulation of RhoB inhibits the dephosphorylation of AKT1 and induces osteosarcoma cell metastasis. Cancer Lett. Aug 1;428:147-159.

11. Liang Y#, Zou Q#, Yu W*. (2017) Steering Against Wind: A New Network of NamiRNAs and Enhancers. Genomics Proteomics Bioinformatics. Oct;15(5):331-337.

12. Luo H, Xi Y, Li W, Li J, Li Y, Dong S, Peng L, Liu Y, Yu W*. (2017) Cell identity bookmarking through heterogeneous chromatin landscape maintenance during the cell cycle. Hum Mol Genet. 26(21):4231-4243.

13. Zou Q, Liang Y, Luo H, Yu W*. (2017) miRNA-Mediated RNAa by Targeting Enhancers. Adv Exp Med Biol. 983:113-125.

14. Xiao M, Li J, Li W, Wang Y, Wu F, Xi Y, Zhang L, Ding C, Luo H, Li Y, Peng L, Zhao L, Peng S, Xiao Y, Dong S, Cao J,  Yu W* (2017) MicroRNAs activate gene transcription epigenetically as an enhancer trigger, RNA Biology, 14:10, 1326-1334, DOI: 10.1080/15476286.2015.1112487

15. Peng L, Li Y, Xi Y, Li W, Li J, Lv R, Zhang L, Zou Q, Dong S, Luo H, Wu F, Yu W*. (2016) MBD3L2 promotes Tet2 enzymatic activity for mediating 5-methylcytosine oxidation. J Cell Sci. 2016 Mar 1;129(5):1059-71.

16. Peng L, Li Y, Zhang L, Yu W*. (2013) Moving RNA moves RNA forward. Sci China Life Sci. 2013 Oct;56(10):914-20.

17. Yu W, Gius D, Onyango P, Muldoon-Jacobs K, Karp J, Feinberg AP, Cui H. (2008) Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA. Nature. Jan 10;451(7175):202-6.

18. Yu W, Ginjala V, Pant V, Chernukhin I, Whitehead J, Docquier F, Farrar D, Tavoosidana G, Mukhopadhyay R, Kanduri C, Oshimura M, Feinberg AP, Lobanenkov V, Klenova E, Ohlsson R. (2004) Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation. Nat Genet. Oct;36(10):1105-10. Epub 2004 Sep 7.

19. Bjornsson HT, Sigurdsson MI, Fallin MD, Irizarry RA, Aspelund T, Cui H, Yu W, Rongione MA, Ekstr?m TJ, Harris TB, Launer LJ, Eiriksdottir G, Leppert MF, Sapienza C, Gudnason V, Feinberg AP. (2008) Intra-individual change over time in DNA methylation with familial clustering. JAMA. Jun 25;299(24):2877-83.

20. Mukhopadhyay R, Yu W, Whitehead J, Xu J, Lezcano M, Pack S, Kanduri C, Kanduri M, Ginjala V, Vostrov A, Quitschke W, Chernukhin I, Klenova E, Lobanenkov V, Ohlsson R. (2004) The binding sites for the chromatin insulator protein CTCF map to DNA methylation-free domains genome-wide. Genome Res. Aug;14(8):1594-602. Epub 2004 Jul 15.

21. Sun L, Huang L, Nguyen P, Bisht KS, Bar-Sela G, Ho AS, Bradbury CM, Yu W, Cui H, Lee S, Trepel JB, Feinberg AP, Gius D. (2008) DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation. Cancer Res. Apr 15;68(8):2726-35.

22. Chernukhin I, Shamsuddin S, Kang SY, Bergstr?m R, Kwon YW, Yu W, Whitehead J, Mukhopadhyay R, Docquier F, Farrar D, Morrison I, Vigneron M, Wu SY, Chiang CM, Loukinov D, Lobanenkov V, Ohlsson R, Klenova E. (2007) CTCF interacts with and recruits the largest subunit of RNA polymerase II to CTCF target sites genome-wide. Mol Cell Biol. Mar;27(5):1631-48. Epub 2007 Jan 8.