Martin Hirst 副教授

英属哥伦比亚大学

个人网页:

http://www.chibi.ubc.ca/faculty/martin-hirst/


研究方向:

主要研究DNA以及组蛋白化学修饰对基因表达调控的作用，以及表观基因组在人类疾病发展，组织分化，维持干细胞多能性等方面发挥的功能。

近期发表论文:

1.Mack, S. C., Hirst, M., et al. (2014) Epigenomic alterations define lethal CIMP-positive ependymomas of infancy.  Nature  February 26; 506:445-450.

2.Nguyen, Hirst, M. et al. (2014)Clonal analysis via barcoding reveals diverse growth and differentiation of transplanted mouse and human mammary stem cells. Cell stem cell  February 6; 14:253-263.

3.Johnson, Hirst, M. et al. (2014) Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma.  Science  January 10; 343:189-193.

4.Zhang, B., Hirst, M. et al. (2013)Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm. Genome research June 13; 23:1522-1540. 

5.Stevens, M., Hirst, M., et al. ( 2013) Estimating absolute methylation levels at single-CpG resolution from methylation enrichment and restriction enzyme sequencing methods. Genome research  June 13; 23:1541-1553.