邓大君 教授
北京大学肿瘤医院/研究所病因学研究室


个人主页：
http://teach.bjcancer.org/postgraduate/planofzhaosheng/daoshi_intro.aspx?peopleleibie=2&peopleid=89

研究方向：   

1.DNA甲基化等修饰的功能及其与肿瘤发生发展关系：研究P16等、基因CpG岛甲基化等修饰的启动、维持、去除及其调节基因转录的分子机制及其与细胞恶性转化和肿瘤细胞侵袭/转移的关系；
2.肿瘤标志物研究：筛选可用做肿瘤预防、诊断、预后判断和放化疗疗效预测的肿瘤DNA甲基化标志物，建立诊断用方法，开发诊断试剂盒；
3.表观遗传实验性转录治疗方法探索。
近期发表论文：
         
1.Chenghua Cui, Ying Gan, Liankun Gu, James Wilson, Zhaojun Liu, Baozhen Zhang*, Dajun Deng*. P16-specific DNA methylation by engineered zinc finger methyltransferase inactivates gene transcription and promotes cancer metastasis. Genome Biology 16:252, 2015
2.Hongwei Liu, Xue-wei Liu, Guangying Dong, Jing Zhou, Yang Liu, Yan Gao, Xiao-yong Liu, Liankun Gu, Zheng Sun*, Dajun Deng*. P16 Methylation as an Early Predictor for Cancer Development from Oral Epithelial Dysplasia: A Double-Blind Multicentre Prospective Study. EBioMedicine 2(5): 432-7, 2015
3.Chenghua Cui, Zheming Lu, Liu Yang, Yanhong Gao, Liankun Gu, Chen Yang, Zhiqian Zhang, Baocai Xin*, Dajun Deng*, Zhongsheng Sun. Genome-wide identification of differential methylation between primary and recurrent hepatocellular carcinomas. Mol Carcinogenesis 2015, doi: 10.1002/mc.22359
4.Xiang Zheng, Jing Zhou, Baozhen Zhang, Jun Zhang, James Wilson, Liankun Gu, Budong Zhu, Jin Gu, Jiafu Ji, Dajun Deng*. Critical evaluation of Cbx7 downregulation in primary colon carcinomas and its clinical significance in Chinese patients. BMC Cancer 15: 145, 2015
5.Zhaojun Liu, Jun Zhang, Yanhong Gao, Lirong Pei, Jing Zhou, Liankun Gu, Lianhai Zhang, Budong Zhu, Naoko Hattori, Jiafu Ji, Yasuhito Yuasa, Wooho Kim, Toshikazu Ushijima, Huidong Shi*, Dajun Deng*. Large-scale characterization of DNA methylation changes in human gastric carcinomas with and without metastasis. Clin Cancer Res 20(17): 4598-612, 2014