马端 教授

复旦大学

个人网页：

http://www.mdlab.fudan.edu.cn


研究方向：
1. 出生缺陷的发病机制及干预
  重点围绕先天性心脏病、先天智障、遗传性耳聋、地中海贫血、戈谢氏病等出生缺陷，寻找并确定遗传、环境和表观遗传病因，阐明发病机制，建立预警和早期诊断方法，研究基因治疗和干细胞治疗方法。
2. 血管性疾病的发病机制及治疗方法
  针对动脉粥样硬化、冠心病和血栓性疾病，重点研究血糖、肠道菌群失调、组织因子及其抑制物的变异及表观遗传修饰变化对血管功能的影响，研发抗凝生物技术新药和个性化益生菌。

近期发表论文:
        
1.Wang J, Xiao J, Wen D, Wu X, Mao Z, Zhang J, Ma D*. Endothelial cell-anchored tissue factor pathway inhibitor regulates tumor metastasis to the lung in mice. Mol Carcinog. 2015 May 6. doi: 10.1002/mc.22329. [Epub ahead of print]
2.Liang F, Diao L, Liu J, Jiang N, Zhang J, Wang H, Zhou W, Huang G, Ma D*. Paternal ethanol exposure and behavioral abnormities in offspring: Associated alterations in imprinted gene methylation. Neuropharmacology.  2014;81:126-33
3.Zhang J, Luo X, Ma XJ, Wu Y, Li WC, Wang HJ, Huang GY*, Ma D*. MicroRNA deregulation in right ventricular outflow tract myocardium in nonsyndromic tetralogy of fallot. Canadian Journal of Cardiology. 2013;29(12):1695-703
4.Li J, Cao Y, Ma XJ, Wang HJ, Zhang J, Luo X, Chen W, Wu Y, Meng Y, Zhang J, Yuan Y, Ma D*, Huang GY. Roles of miR-1-1 and miR-181c in ventricular septal defects. Int J Cardiol. 2013;168(2):1441-6
5.Xu C, Deng F, Mao Z^, Zhang J, Wang H, Wang J, Mu J, Deng S, Ma D*. The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells. Biochemical Journal，2012;441(2):665-74.