演讲嘉宾简介

											
倪挺 教授

复旦大学生命科学学院

个人网页:

http://life.fudan.edu.cn/Data/View/1391

研究方向:

  1.选择性多聚腺苷酸化及在细胞衰老中的功能及机制:主要开展全基因组水平的选择性多聚腺苷酸化(Alternative Polyadenylation, APA)检测及其在细胞衰老中的功能和机制研究。
  2.内含子保留在T细胞活化中的功能及机制:发现哺乳动物T细胞中全局性内含子保留的基因调控新现象。后续开展内含子保留的下游功能和上游调控机制。


近期发表论文:
        
1.Ni T#, Corcoran DL#, Rach EA, Song S, Spana EP, Gao Y, Ohler U* and Zhu J*. A paired-end sequencing strategy to map the complex landscape of transcription initiation. Nature Methods. 2010; 7: 521-527. (IF:32.072)

2.Ni T#*, Yang Y#, Hafez D, Yang W, Kiesewetter K, Wakabayashi Y, Ohler U, Peng W and Zhu J*. Distinct polyadenylation landscapes of diverse human tissues revealed by a modified PA-seq strategy. BMC Genomics. 2013; 14(1):615. (IF:3.986)

3.Majerciak V#, Ni T#, Yang W, Meng B, Zhu J* and Zheng ZM.* A viral genome landscape of RNA polyadenylation from KSHV latent to lytic Infection. PLoS Pathogens. 2013; 9(11):e1003749.(IF:7.562)

4.Ni T#*, Wei G#, Shen T, Han M, Lian Y, Fu H, Luo Y, Yang Y, Liu J, Wakabayashi Y, Li Z, Finkel T, Xu H, Zhu J*. MitoRCA-seq reveals unbalanced cytocine to thymine transition in Polg mutant mice. Scientific Reports. 2015; 5:12049. doi: 10.1038/srep12049. (IF:5.578)

5.Yu M#, Yang W#, Ni T, Tang Z, Nakadai T, Zhu J, Roeder RG*. RNA Polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA Polymerase II. Science. 2015; 350(6266):1383-6.(IF:33.611)