于文强 教授

复旦大学生物医学研究院

个人网页:

http://www.ibsfudan.org/show.aspx?info_lb=85&flag=3&info_id=842

研究方向：   
1. 非编码RNA调控 
2. 表观遗传学与重大疾病

近期发表论文：
   
1.Yu W, Gius D, Onyango P, Muldoon-Jacobs K, Karp J, Feinberg AP, Cui H. Epigenetic  silencing of tumour suppressor gene p15 by its antisense RNA. Nature. 2008 Jan  10;451(7175):202-6. （IF：28.751）

2.Yu W, Ginjala V, Pant V, Chernukhin I, Whitehead J, Docquier F,  Farrar D, Tavoosidana G, Mukhopadhyay R, Kanduri C, Oshimura M, Feinberg AP,  Lobanenkov V, Klenova E, Ohlsson R. Poly(ADP-ribosyl)ation regulates  CTCF-dependent chromatin insulation. Nat Genet. 2004 Oct;36(10):1105-10. Epub  2004 Sep 7. （IF：24.695）

3.Bjornsson HT, Sigurdsson MI,  Fallin MD, Irizarry RA, Aspelund T, Cui H, Yu  W, Rongione MA, Ekstr?m TJ, Harris TB, Launer LJ, Eiriksdottir G, Leppert  MF, Sapienza C, Gudnason V, Feinberg AP. Intra-individual change over time in  DNA methylation with familial clustering.JAMA. 2008 Jun 25;299(24):2877-83.（IF：25.547）

4.Sun L, Huang L, Nguyen P, Bisht  KS, Bar-Sela G, Ho AS, Bradbury CM, Yu  W, Cui H, Lee S, Trepel JB, Feinberg AP, Gius D. DNA methyltransferase 1  and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation  of promoter histone methylation.Cancer Res. 2008 Apr 15;68(8):2726-35. （IF：7.672）

5.Chernukhin I, Shamsuddin S, Kang  SY, Bergstr?m R, Kwon YW, Yu W,  Whitehead J, Mukhopadhyay R, Docquier F, Farrar D, Morrison I, Vigneron M, Wu  SY, Chiang CM, Loukinov D, Lobanenkov V, Ohlsson R, Klenova E. CTCF interacts  with and recruits the largest subunit of RNA polymerase II to CTCF target sites  genome-wide.Mol Cell Biol. 2007 Mar;27(5):1631-48. Epub 2007 Jan 8.（IF：6.42）

6.Mukhopadhyay R, Yu W, Whitehead J, Xu J, Lezcano M,  Pack S, Kanduri C, Kanduri M, Ginjala V, Vostrov A, Quitschke W, Chernukhin I,  Klenova E, Lobanenkov V, Ohlsson R. The binding sites for the chromatin  insulator protein CTCF map to DNA methylation-free domains genome-wide.Genome  Res. 2004 Aug;14(8):1594-602. Epub 2004 Jul 15.（IF：10.382）