Ali Mortazavi Assistant Professor
University of California Irvine
研究方向:
His research interests are in the application of genomic methods to answer fundamental questions in the transcriptional regulation of development using a combination of functional sequencing assays and computational methods. I am particularly interested in understanding how homologous gene regulatory networks are encoded in the human and mouse genomes. I have also a separate interest in comparative genomics and development of nematode parasites with a particular focus on the genus Steinernema. His lab combines experimental work and computational analysis primarily in hematopoietic, skeletal muscle, and embryonic stem cells in human, mouse, and other mammals to understand which regulatory elements are
conserved, which elements are not conserved but functional, and which elements regulates what genes. His laboratory has focused over the last six years on doing comparative analyses of regulatory elements and their long-range interactions in human and mouse using a combination of ChIP-seq, DNA methylation, ATAC-seq and RNA-seq using ever lower amounts of starting material down to single cells when practical. His long term goals are (a) to develop models that take into account the complex interplay of promoters and enhancers in controlling gene expression and (b) to understand the common and species-specific parts of the human and mouse Gene Regulatory Networks for homologous cell types and tissues in order to translate seamlessly results between human and mouse models of disease. I have actively participated in ENCODE since 2008, first at Caltech and now in his own lab at UCI.
近期发表论文:
1. Assessment of transcript reconstruction methods for RNA-seq Steijger T, Abril JF, Engström PG, Kokocinski F; The RGASP Consortium, Akerman M, Alioto T, Ambrosini G, Antonarakis SE, Mortazavi A, and et al. Nature Methods, 2013, In press
2. Integrating and mining the chromatin landscape of cell type specificity using Self-Organizing Maps Mortazavi A*$, Pepke S*, Jansen C, Marinov GK, Ernst J, Kellis M, Hardison R, Myers RM, Wold B$ Genome Research, 2013, In press *first co-authors, $corresponding authors
3. The common ground of genomics and systems biology Conesa A, Mortazavi A, BMC Systems Biology, 2013, In press
4. The Draft Genome and Transcriptome of Panagrellus redivivus are shaped by the harsh demands of a free- living lifestyle Srinivasan J, Dilman AR, Macchietto MG, Heikkinen L, Lakso M, Fracchia KM, Antoshechkin I, Mortazavi A, Wong G, Sternberg PW Genetics 2013
5. Park E, Williams B, Wold B, Mortazavi A (2012) RNA Editing in the ENCODE RNA-seq data. Genome Research.
