Jay D. Horton Professor

UT Southwestern MedicalCenter





研究方向:

Jay D. Horton obtained his B.S. and M.D. degrees from the University of Iowa in 1984 and 1988, respectively. He completed his internal medicine residency (1988- 1991) and gastroenterology fellowship (1991-1994) at UT Southwestern Medical Center. In clinical digestive diseases, Dr. Horton has an interest in conditions that lead to steatosis and obesity. Currently the laboratory is investigating molecular mediators of steatosis using various mouse models. Investigations from the laboratory have revealed how the primary transcriptional regulators of cholesterol metabolism (sterol regulatory element-binding proteins) are also key regulators of fatty acid synthesis in liver.A major focus of the laboratory is to determine how these transcriptional
regulators contribute to the development of steatosis in various disease processes such as diabetes, obesity, and beta-oxidation defects.A second area of investigation centers on determining the function of PCSK9, a protein that is involved in determining plasma LDL cholesterol levels through its ability to post- transcriptionally regulate the expression of the LDL receptor in liver.

近期发表论文:


1.Y-A. Moon, C.R. Ochoa, M.A. Mitsche, R.E. Hammer, J.D. Horton. 2014. Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance. J. Lipid Res. 55:2597-2605. PMCID: PMC4242452.
2.S.A. Comerford, Z. Huang, X. Du, Y. Wang, L. Cai, A.K. Witkiewicz, H. Walters, M.N. Tantawy, A. Fu, H.C. Manning, J.D. Horton, R.E. Hammer, S.L. McKnight, B.P. Tu. 2014. Acetate dependence of tumors. Cell. 159:1591-602. PMCID: PMC4272450.
3.L. Goedeke, N. Rotllan, A. Canfran-Duque, J.F. Aranda, C.M. Ramirez, E. Araldi, C.S. Lin, N.N. Anderson, A. Wagschal, R. de Cabo, J.D. Horton, M.A. Lasuncion, A.M. Naar, Y. Suarez, C. Fernandez-Hernando. 2015. MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels. Nat. Med. 11:1280-1289. PMCID: PMC4711995.
4.P. Bartuzi, D.D. Billadeau, J.D. Horton, E. Burstein, M.H. Hofker, B. van de Sluis, et al. 2016. CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Nat. Commun. Mar 11;7:10961. PMCID: PMC4792963.
5.K. Fizgerald, S. White, A. Borodovsky, B.R. Bettencourt, A. Strahs, V. Clausen, P. Wijngaard, J.D. Horton, J. Taubel, A. Brooks, F. Chamikara, R.S. Kauffman, D. Kallend, A. Vaishnaw, and A. Simon. 2016. A highly durable RNAi therapeutic inhibitor of PCSK9. N. Engl. J. Med. In Press. PMCID: PMC – Journal in Process.