雷群英 教授

复旦大学





研究方向:

肿瘤代谢，Hippo-TAZ 信号通路，蛋白 质翻译后修饰及其生理病理效应。


近期发表论文:

1.Wang YP*，Wang J，Gao X, Xu YY, Cheng JK*, Lei QY*. Arginine Methylation of MDH1 by CARM1 Inhibits Non-canonical Glutamine Metabolism and Suppresses Pancreatic Cancer. Molecular Cell. 2016， 64, 673–687. Highlights:Cancer Discovery
2.Gao X#, Lin SH#，Ren F, Li1 JT, Chen JJ, Yao CB,Yang HB,Jiang SX, Yan GQ, Wang D， Wang Y, Liu Y, Cai Z, Xu YY, Chen J, Yu W, Yang YP*, Lei QY*. Acetate Functions as an Epigenetic Metabolite to Promote Lipid Synthesis under Hypoxia. Nature Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960
3.Lin R#, Ren T#, Gao X, Zhou X, Li T, Xiong Y, Guan KL, Lei QY*. Acetylation Stabilizes ATP-citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth. Molecular Cell 2013, 51:506–518.
4.Zhao D#, Zou S#, Liu Y, Zhou X, Mo Y, Wang P, Xu Y, Dong B, Xiong Y*, Lei QY* and Guan KL*. Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer. Cancer Cell 2013, 23:464-476.
5. Li Z, Xu Y, Huang Y, Gang W, Xiong Y, Guan KL and Lei QY*. Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth. Molecular Cell 2011, 42:719-730. Feature article