Yin Shen Assistant Professor

University of California at San Francisco





研究方向:

They study the fundamental mechanisms of transcriptional control. By investigating how genetic and epigenetic variations contribute to cis- regulatory elements function, they will develop a detailed understanding how cis-regulatory elements contribute to cell fate determination and health. These studies will lead to a better comprehension of development, and will facilitate
the improvement and advancement of preventive methods, diagnoses, and treatments for diseases.

近期发表论文:

1. Diao Y, Fang R, Li B, Meng Z, Yu J, Qiu Y, Lin KC, Huang H, Liu T, Marina RJ, Jung I, Shen Y, Guan K, Ren B. (2017) A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells. Nature Method, 2017 Apr 17. [Epub ahead of print]
2. He Y, Gorkin D, Dickel D, Nery J, Castanon R, Lee AY, Shen Y, Visel A, Pennacchio L, Ren B, Ecker J. (2017) Improved regulatory element prediction based on tissue-specific local epigenomic signatures. PNAS, 2017 Jan 9;114(9):1633-1640.
3. Diao Y*, Li B, Young I, Lee AY, Meng Z, Maliskova L, Guan K, Shen Y*,#, Ren B#. (2015) A New Class of Temporarily Phenotypic Enhancers Identified by CRISPR/Cas9 Mediated Genetic Screening. Genome Research, 2016 Jan 26. [Epub ahead of print] (*equal contribution, # co- correspondence author). PMID: 26813977
4. Dixon JR*, Jung I*, Selvaraj S*, Shen Y, Antosiewicz-Bourget JE, Lee AY, Ye Z, Kim A, Rajagopal N, Xie W, Diao Y, Liang J, Zhao H, Lobanenkov VV, Ecker JR, Thomson JA, Ren B. (2015) Chromatin architecture reorganization during stem cell differentiation. Nature 2015; 518 (7539): 33.
5. Yue F*, Cheng Y*, Breschi A*, Vierstra J*, Wu W*, Ryba T*, Sandstrom R*, Ma Z*, Davis C*, Pope BD*, Shen Y*, et al (with another 126 authors) (2014) A comparative encyclopedia of DNA elements in the mouse genome. Nature, 2014 Nov 20;515(7527):355-64. (*co-first author)