Qian Tao Professor

The Chinese University of HongKong





研究方向:

从事表观遗传组学(epigenomics)与肿瘤, 分子标志物和表 观遗传治疗研究。已完成多个常见肿瘤的精密甲基化组学谱 (methylome), 鉴定了多个被甲基化的新抑癌基因如 PCDH10, RASAL1, ZNF382, BLU, IRF8, TET1, BCL6B, DACT2, JPH3 等, 并阐明及在肿瘤发生中的功能、分子机制及作为肿瘤标志物的潜力。


近期发表论文:

1. WNT5A antagonizes WNT/β-catenin signaling and is frequently silenced by promoter CpG methylation in esophageal squamous cell carcinoma. Li J, Ying J, Fan Y, Wu L, Ying Y, Chan AT, Srivastava G, Tao Q. Cancer Biol Ther. 2010 Sep 15;10(6):617-24. Epub 2010 Sep 7
2. WNT5A exhibits tumor-suppressive activity through antagonizing the Wnt/beta-catenin signaling, and is frequently methylated in colorectal cancer. Ying J, Li H, Yu J, Ng KM, Poon FF, Wong SC, Chan AT, Sung JJ, Tao Q. Clin Cancer Res. 2008 Jan 1;14(1):55-61.
3. Epigenetic disruption of the WNT/beta-catenin signaling pathway in human cancers.Ying Y, Tao Q. Epigenetics. 2009 Jul 1;4(5):307-12.
4. KRAB zinc finger protein ZNF382 is a proapoptotic tumor suppressor that represses multiple oncogenes and is commonly silenced in multiple carcinomas. Cheng Y, Geng H, Cheng SH, Liang P, Bai Y, Li J, Srivastava G, Ng MH, Fukagawa T, Wu X, Chan AT, Tao Q.Cancer Res. 2010 Aug 15;70(16):6516-26
5. OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation. Cui Y, Ying Y, van Hasselt A, Ng KM, Yu J, Zhang Q, Jin J, Liu D, Rhim JS, Rha SY, Loyo M, Chan AT, Srivastava G, Tsao GS, Sellar GC, Sung JJ, Sidransky D, Tao Q.PLoS One. 2008 Aug 20;3(8):e2990.