Zefeng Wang  Principal investigator

CAS-MPG Partner Institute for Computational Biology, CAS





研究方向:

人类基因组测序带来的最惊人发现之一是，蛋白质编码基因的数量 远远少于以前的估计，而基因组的额外复杂性主要是在 RNA 加工过程中 引入的。人类的绝大多数基因的 pre-mRNA，都经历可变剪接的加工过 程。剪接过程在不同组织和发育阶段受到紧密的调控，而其异常调控则 和许多疾病的发生相关。我们的长期研究目标，是要理解剪接过程是如 何在细胞内发生的。我们希望弄清楚剪接调控的一整套可称为“剪接密 码”(splicing code)的规则。通过对“剪接密码”的认识，我们将针对 剪接相关的人类疾病，探索新的治疗方法。

近期发表论文:


1. YangY,FanX,MaoM,SongX,WuP,ZhangY,JinY,YangY,ChenL,WangY,WongCL, Xiao XG, Wang Z, Extensive translation of circular RNAs driven by N6-methyladenosine, Cell research. 2017; in press
2. Hu J, Khodadadi-Jamayran A, Mao M, Shah K, Yang Z, Nasim MT, Wang Z, Jiang H. AKAP95 regulates splicing through scaffolding RNAs and RNA processing factors. Nature communications. 2016; 7:13347. PMID: 27824034, PMCID: PMC5105168
3. Mao H, McMahon JJ, Tsai YH, Wang Z, Silver DL. Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly. PLoS genetics. 2016; 12(9):e1006282. PMID: 27618312, PMCID: PMC5019403
4. Dominguez D, Tsai YH, Gomez N, Jha DK, Davis I, Wang Z. A high-resolution transcriptome map of cell cycle reveals novel connections between periodic genes and cancer. Cell research. 2016; 26(8):946-62. PMID: 27364684, PMCID: PMC4973334
5. LiR,DongQ,YuanX,ZengX,GaoY,ChiaoC,LiH,ZhaoX,KelesS,WangZ,ChangQ. Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome. PLoS genetics. 2016; 12(6):e1006129. PMID: 27352031, PMCID: PMC4924826