William J. Greenleaf Associate Professor

University of Pennsylvania





研究方向:

His Current Research Interests focuses on developing methods to probe the genome and epigenome at the single-cell and single-molecule levels. Their efforts are split between building new tools to leverage the power of high- throughput sequencing and cutting-edge microscopies, and bringing these new technologies to bear against basic biological questions of genomic and epigenomic variation.

近期发表论文:

1. Barajas B*, Rubin AJ*, Furlan-Magaril M, Howard I, Mumbach M, Kim DS, Boxer L, Lopez- Pajares V, Greenleaf WJ, Kundaje A, Snyder M, Chang YM, Fraser P, Khavari PA. “Lineage- specific factors regulate dynamic and constitutive enhancer-promoter contacts to induce terminal differentiation.” In revision at Nature.
2.Mumbach MR, Satpathy AT, Boyle EA, Dai C, Wei Y, Rubin AJ, Nguyen T, Corces MR, Suliman N, Li R, Xu J, Flynn RA, Khavari PA, Quertermous T, Greenleaf WJ§, and Chang HY§. “Enhancer connectome in primary human cells reveals target genes of disease-associated DNA elements” In review at Nature Genetics
3.She R*, Chakravarty AK*, Layton CJ*, Chircus L) M, Andreasson JOL, Damaraju N, McMahon PL, Buenrostro JD, Jarosz DF§, Greenleaf WJ§. “Comprehensive and quantitative mapping of RNA-protein interactions across a transcribed eukaryotic genome.” PNAS. 114(14):3619-24
4.Litzenburger UM, Buenrostro JD, Wu B, Shen Y, Sheffield N, Kathiria A, Greenleaf WJ§, Chang HY§. (2017) Single cell epigenomic variability reveals functional cancer heterogeneity. Genome Biology. 24;18(1):15
5.Xu J, Carter AC, Grendrel AV, Attia M, Loftus J, Greenleaf WJ, Tibshirani R, Heard E, Chang HY. (2017) Landscape of monoallelic DNA accessibility in mouse embryonic stem cells and neural progenitor cells. Nat Genet. doi: 10.1038/ng.3769