Guorui Wu Chair Professor

China Medical University





研究方向:

Dr. Wu is a physician-scientist with training in gene regulation and tumor biology. HIs research includes the molecular mechanism of epithelial- mesenchymal transition (EMT) mediated by hypoxia. Research projects will focus on the identification of HIF-1 and Twist1 target genes and their relationship to EMT and metastasis. Other aspects of biology including epigenetics, protein stability and angiogenesis related to HIF-1 and Twist1 will be explored too.

近期发表论文:

1.Wu, H.T., Kuo, Y.C., Huang, C.H., Hung, J.J., Chen, W.Y., Chou, T.Y., Chen, Y., Y.J. Chen, Y.J. Chen, Cheng, W.C., Teng, S.C., and Wu, K.J. (2016) K63-polyubiquitinated HAUSP deubiquitinates HIF-1 and dictates H3K56 acetylation promoting hypoxia-induced tumor progression. Nature Communications, 7, 13644.
2. Chen, H.F., Huang, C.H., Liu, C.J., Hung, J.J., Hsu, C.C., Teng, S.C., and Wu, K.J. (2014) Twist1 induces endothelial differentiation of tumor cells through the Jagged1-KLF4 axis. Nature Communications, 5, 4697.
3. Tsai, Y.P., Chen, H.F., Chen, S.Y., W.C. Cheng, H.W. Wang, Z.J. Shen, Teng, S.C., Chuan, H., and Wu, K.J. (2014) TET1 regulates hypoxia-induced epithelial-mesenchymal transition by acting as a co-activator. Genome Biology, 15, 513.
4. Wu, M.Z., Tsai, Y.P., Yang, M.H., Huang, C.H., Chang, S.Y., Chang, C.C., Teng, S.C., and Wu, K.J. (2011) Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial- mesenchymal transition. Molecular Cell, 43, 811-822.
5. Yang, M.H., Wu, M.Z., Chiou, S.H., Chang, S.Y., Chen, P.M., Liu, C.J., Teng, S.C., and Wu, K.J. (2008) Direct regulation of TWIST by HIF-1 promotes metastasis. Nature Cell Biology, 10, 295-305.