颉伟 研究员

清华大学生命科学学院





研究方向:

主要科研领域与方向: 研究兴趣包括表观遗传学，基因组学和生物信 息学。运用高通量基因组学，同时利用分子生物学和计算生物学的方法， 采用干湿实验结合的方式，研究干细胞分化和个体发育以及人类疾病中 的表观遗传调控机制。本实验室将致力于:(1)干细胞分化过程中的组 蛋白修饰和 DNA 甲基化介导的表观遗传调控(2)动物胚胎早期发育过 程中的表观遗传调控(3)Cis-regulatory elements 如启动子和增强子在细 胞命运决定过程中的作用 。

近期发表论文:

1.Wei Xie#, Bing Ren# (2013) Enhancing Pluripotency and Lineage Specification, Science 341:245-7 (# co-correspondence authors)
2. Wei Xie, Matthew D. Schultz, Ryan Lister, Zhonggang Hou, Nisha Rajagopal, Pradipta Ray, John W. Whitaker, Shulan Tian, R. David Hawkins, Danny Leung, Hongbo Yang, Tao Wang, Ah Young Lee, Scott A. Swanson, Jiuchun Zhang, Yun Zhu, Audrey Kim, Joseph R. Nery, Mark A. Urich, Samantha Kuan, Chia-an Yen, Sarit Klugman, Pengzhi Yu, Kran Suknuntha, Nicholas E. Propson, Huaming Chen, Lee E. Edsall, Ulrich Wagner, Yan Li, Zhen Ye, Ashwinikumar Kulkarni, Zhenyu Xuan, Wen-Yu Chung, Neil C. Chi, Jessica E. Antosiewicz-Bourget, Igor Slukvin, Ron Stewart, Michael Q. Zhang, Wei Wang, James A. Thomson, Joseph R. Ecker, and Bing Ren (2013) Epigenomic Analysis of Multi-lineage Differentiation of Human Embryonic Stem Cells, Cell 153: 1134-1148).
3. Wei Xie, Cathy L Barr, Audrey Kim, Feng Yue, Ah Young Lee, James Eubanks, Emma L Dempster and Bing Ren (2012) Base-resolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome, Cell 148: 816-831.
4. Wei Xie, Chunying Song, Nicolas L. Young, Adam Sperling, Feng Xu, Rupa Sridharan, Anne Conway, Benjamin A. Garcia, Kathrin Plath, Amander Clark and Michael Grunstein (2009) Histone H3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells, Molecular Cell, 33(4):417-427.