Kun Zhang Professor

University of California at SanDiego





研究方向:

张鲲课题组的主要研究方向包括:
1. CRISPR/Cas9 介导的高通量基因分析系统研究调控元件功能;
2. 细胞特异性的基因调控机制研究;
3. 神经性疾病中顺式调控元件引起的基因突变研究。

近期发表论文:


1.Emmerson E, May A, Nathan S, Pacheco NC, Lizama CO, Maliskova L, Zovein AC, Shen Y, Muench MO, Knox SM. (2017) SOX2 regulates acinar cell development in the salivary gland. eLIFE, 2017, Jun 17. [Epub ahead of print]
2.Diao Y, Fang R, Li B, Meng Z, Yu J, Qiu Y, Lin KC, Huang H, Liu T, Marina RJ, Jung I, Shen Y, Guan K, Ren B. (2017) A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells. Nature Method, 2017 Apr 17. [Epub ahead of print]
3.He Y, Gorkin D, Dickel D, Nery J, Castanon R, Lee AY, Shen Y, Visel A, Pennacchio L, Ren B, Ecker J. (2017) Improved regulatory element prediction based on tissue-specific local epigenomic signatures. PNAS, 2017 Jan 9;114(9):1633-1640.
4.Diao Y*, Li B, Young I, Lee AY, Meng Z, Maliskova L, Guan K, Shen Y*,#, Ren B#. (2016) A New Class of Temporarily Phenotypic Enhancers Identified by CRISPR/Cas9 Mediated Genetic Screening. Genome Research, 2016 Jan 26. [Epub ahead of print] (*equal contribution, # co- correspondence author).
5.Dixon JR*, Jung I*, Selvaraj S*, Shen Y, Antosiewicz-Bourget JE, Lee AY, Ye Z, Kim A, Rajagopal N, Xie W, Diao Y, Liang J, Zhao H, Lobanenkov VV, Ecker JR, Thomson JA, Ren B. (2015) Chromatin architecture reorganization during stem cell differentiation. Nature 2015; 518 (7539): 33.